Full project title: “Lensless holographic microscope enabling high-throughput, label-free studies of biomedical samples”. The goal of the μHOLLO project is to develop a new product – a lensless holographic microscope (LHM) that enables rapid and non-invasive analysis of large measurement volumes for biomedical applications, such as histopathological analysis of tissue sections and phenotyping and counting cells without the need for staining (a costly and time-consuming process harmful to living samples). By not using a microscope objective, the LHM is free from limitations of the field of view, depth of focus, and aberrations associated with imaging optical elements. The LHM is based on Gabor holography, which works well for weakly scattering objects but struggles with analyzing thicker samples that carry critical three-dimensional information about the studied object. The innovation of the planned new product lies in the use of illumination with a tailored degree of spatiotemporal coherence and wavelength, as well as new holographic reconstruction algorithms specialized for biological objects.

Principal Investigator: Prof. Maciej Trusiak

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